Drug Interactions Between Dolutegravir and Escalating Doses of Rifampicin

Exclusion Criteria

• •\< 18 years
• •Body weight \< 50 kg
• •eGFR \< 60 mL/min
• •Abnormal LFTs including ALT \> 2.5 ULN
• •HIV antibody positive
• •Non-standard TB regimen (containing RHZE)
• •Women of childbearing age unless using effective contraception
• •Family history of sudden cardiac death
• •Prior history of cardiac disease that precludes the use of low dose digoxin
• •Medical or psychiatric condition that might affect participation in the study based on investigator judgement
• •Regular consumption of grapefruit or grapefruit juice
• •ECG abnormalities that preclude the use of low dose digoxin (intermittent complete heart block, second degree AV block, supraventricular arrhythmia associated with conducting pathways, ventricular tachycardia or fibrillation)