Neurocircuit Strategy to Decrease Cocaine Cue Reactivity

Exclusion Criteria

• •1. Past head injury or primary neurological disorder associated with MRI abnormalities, including dementia, MCI, brain tumors, epilepsy, Parkinson's disease, or demyelinating diseases
• •2. Any physical or intellectual disability affecting completion of assessments
• •3. Any contraindication to MRI
• •4. Current or past psychosis
• •5. ECT in last 6 months
• •6. Among females, pregnancy at screening will be exclusionary. Females of child bearing potential must agree to undergo a pregnancy test 72 hours prior to the fMRI scanning session and regularly before and during the medication trial. They must further agree to notify the study physician or PA if they become pregnant during the study.
• •7. Clinical Institute Withdrawal Assessment (CIWA-Ar) scale will be used to assess alcohol withdrawal. Individuals with CIWA \> 8 will be excluded.
• •8. Individuals with unstable medical illness (e.g., hypertension, diabetes, myocardial infarction)
• •9. Has current suicidal ideation or homicidal ideation.
• •10. Has the need for maintenance or acute treatment with any psychoactive medication including anti-seizure medications and medications for ADHD
• •11. Suffers from chronic migraines
• •12. Any physical or intellectual disability affecting completion of assessments