Effect of Inhaled TD-8236 on Allergen-induced Asthmatic Response

Inclusion Criteria

• •Male or female, 18 to 65 years of age
• •Willing and able to give informed consent and comply with study requirements
• •Documented physician-diagnosed asthma for ≥ 4 months prior to Screening
• •Body mass index (BMI) ≥ 18.0 and ≤ 35.0 kg/m2 at Screening and weighs ≥ 50 kg at Screening.
• •Women of child bearing potential must have a negative pregnancy test
• •Males and females must use a highly efficient birth control method
• •Pre-bronchodilator FEV1 ≥ 70% predicted
• •Documented allergy to at least one common allergen
• •Dual responder to inhaled bronchial challenges