Effects of Probiotic Mixture Supplementation and Evaluation of Intestinal Mucosal Tolerance and Gut Microbiome in Newborns With Perinatal Asphyxia Receiving Hypothermic Treatment

Inclusion Criteria

• •o Newborns with gestational age \>/= 35 weeks and birth weight \>/= 1800 grams
• •o Intrapartum asphyxia defined according at least one of the following:
• •APGAR index at 10 minutes \</=5;
• •Resuscitation with endotracheal tube or mask IPPV for more then 10 minutes;
• •pH \</= 7 or excess of base \>/= 12 mmol/l on arterial blood gas (ABG) analysis within the first 60 minutes of life
• •* Moderate/severe Hypoxic-ischemic encephalopathy assessed between 30 and 60 minutes of life according to Sarnat \& Sarnat definition
• •* Hypothermic treatment. According to the Italian national guidelines on Perinatal Asphyxia and Therapeutic Hypothermia, the hypothermic therapy will be started in the first six hours of life and will last 72 hours.