Study Evaluating Safety and Efficacy of UCART Targeting CS1 in Patients With Relapsed/Refractory Multiple Myeloma (MELANI-01)

Exclusion Criteria

• •Previous treatment with investigational gene therapy targeting CS1 or chimeric antigen receptor therapy targeting CS1;
• •Any cellular therapy (other than autologous or allogenic HSCT) within 60 days prior to enrollment;
• •Prior treatment with rituximab or other anti-CD20 therapy within 3 months
• •Any known active or uncontrolled infection
• •Autologous hematopoietic stem cell transplantation (HSCT) within 12 weeks prior to enrollment; any cellular therapy (other than autologous) within 60 days prior to enrollment; prior allogeneic HSCT.
• •Seropositive for Hepatitis C virus or positive for Hepatitis B surface antigen or core antibody.
• •Presence of active and clinically relevant central nervous system disorder, such as epilepsy, generalized seizure disorder, paresis, aphasia, stroke, severe brain injury, dementia, Parkinson's disease, cerebellar disease, or organic brain syndrome.