EXOME Analysis Position in the Strategy of Genetic Predisposition Factors Identification in Early-onset Cancer

Inclusion Criteria

• •Index case:
• •1. Major or minor patient
• •2. Histological or cytological evidence of malignant tumor diagnosis
• •3. Patient with cancer before age 40 (or before age 30 for breast cancer).
• •4. Absence of anomaly found on the oncogenetic panel tested in the predisposition concerned
• •5. Patient affiliated to a social security scheme
• •6. Signature of Informed Consent EXTRICAN
• •7. Availability of a tumor sample if needed secondary functional studies
• •8. Availability of both parents when the trio approach will be necessary in the population 1 (or validation of the indication in CPR in case of non-availability of both parents)
• •9. Availability of affected relatives in population 2 (or validation of the indication in SPC in case of non-availability of the related person)
• •Related:
• •1. Major or minor patient
• •2. Histological or cytological evidence of the diagnosis of malignant tumor if
• •3. Patient affiliated to a social security scheme
• •4. Signing informed consent EXTRICAN