Lead Sponsor

Otonomy, Inc.

Age

21 - 64 years

Sex

ALL

Healthy Volunteers

No

•Subject has audiometrically-defined normal hearing or up to moderately severe hearing impairment.
•Subject has self-reported difficulty hearing in noisy environments for at least 6 months prior to Screening.
•Subject exhibited a speech-in-noise hearing deficit in at least one ear.

•Subject is pregnant or lactating.
•Subject has the following hearing disorders or any other hearing disorders that may impact the efficacy assessments or safety of the subject in the opinion of the Investigator: Meniere's disease, congenital hearing loss, or genetic sensorineural hearing loss.
•Subject has a cochlear implant or consistently uses a hearing aid.
•Subject has worked at least 5 years as a professional musician or has had at least 15 years of formal musical training.
•Subject self-reports bothersome, subjective tinnitus and is consistently aware of their tinnitus throughout much of the waking day.