Sponsors

Lead Sponsor

Wake Forest University Health Sciences

Age

18 - 90 years

Sex

FEMALE

Healthy Volunteers

No

Inclusion Criteria

•Female gender
•At least 18 years of age
•Have already decided to undergo intradetrusor Botox® injections for treatment of refractory overactive bladder.
•Able and willing to learn clean intermittent catheterization (or care provider is willing and able to perform intermittent catheterization).
•Understands and is willing to undergo follow up and complete questionnaires as described in this protocol
•Able to give informed consent

Exclusion Criteria

•Male gender
•Neurological conditions (Examples: Cerebral vascular accident within 6 months prior to treatment, Parkinson's disease, Multiple Sclerosis, and Spina Bifida).
•Acute urinary tract infection
•Treatment with Botox® toxin for other conditions
•Allergy to Botox® toxin
•Hematuria that has not been worked up
•Known bladder malignancy
•Previous history of bladder augmentation
•Currently pregnant (with no plans to become pregnant within 6 months of enrollment) or breastfeeding
•Currently taking aminoglycoside antibiotics
•Post-void residual (PVR) \>150 cc (measured by bladder scan or by catheterization) prior to enrollment
•History of chronic pain or pain syndromes

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