Dietary Fibers Effect on the Gut Microbiota Composition

Exclusion Criteria

• •High or very high cardiovascular risk
• •Levels of total cholesterol and/or low-density lipoproteins requiring immediate assignment of drug treatment (according to ESC Guidelines for the management of dyslipidaemias, 2019)
• •Diabetes mellitus of any type
• •HbA1с of 5,7% or higher
• •Obesity requiring medical therapy or surgery (according to European Guidelines for Adult Obesity Management, 2019)
• •Gastrointestinal diseases in history including ulcerative colitis, Crohn's disease, celiac disease, gallbladder disease (calculous cholecystitis, cholangitis, etc.) not related to functional disorders; liver or pancreas diseases
• •Irritable bowel syndrome, abdominal pain of any location and etiology
• •Pain syndrome of any localization
• •Flatulence
• •Oncology diseases
• •Mental disorders
• •Rheumatoid arthritis or other autoimmune diseases
• •Acute infectious diseases or exacerbation of any diseases
• •Recent (\<3 months) administration of proton pump inhibitors, antimicrobial therapy or surgical intervention
• •Recent (\<3 weeks) use of probiotics, antacids, nonsteroidal anti-inflammatory drugs, laxatives
• •Pregnancy, planning to be pregnant or breast feeding at any point during the study or study enrollment
• •Current alcohol/drug abuse (more than 3 points for women and 4 for men according to AUDIT-C questionnaire and/or more than 7 points on the AUDIT questionnaire) or addiction therapy within 12 months prior to screening
• •Allergies to any prebiotic or placebo ingredients
• •Planned relocation from the home region during the study