Adrenomedullin Effect on Migraine Without Patients

Exclusion Criteria

• •Tension-type headaches more than 5 days a month on average over the past year.
• •All other primary headache forms.-
• •Headache later than 48 hours before the start of the trial.
• •Daily intake of medicines of all kinds except oral contraception.
• •Taking any medicine later than 4 times the plasma half-life of that drug (on the day of the trial), except oral contraception.
• •Pregnant or breastfeeding women.
• •Headache on the day of the trial or later than 48 hours before the administration of the trial drug / placebo
• •Migraines within 3 days before the trial date.
• •Anamnestic information or clinical signs (on the day of inclusion):
• •Hypertension (systolic blood pressure\> 150 mmHg and / or diastolic blood pressure\> 100 mmHg)
• •Hypotension (systolic blood pressure \<90 mm Hg and / or diastolic blood pressure \<50 mmHg)
• •Cardiovascular diseases of all kinds, including cerebrovascular diseases.
• •Anamnestic or clinical signs of mental illness or abuse.
• •Patients with glaucoma or prostate hyperplasia
• •Anamnestic or clinical signs of illness of any kind that the investigating physician considers relevant for participation in the trial.