Clinical Trial to Assess the Efficacy of µSmin® Plus

Exclusion Criteria

• •Patients suffering from other or associated vascular diseases, diabetes or bleeding disorders;
• •Oedema of the lower limbs of cardiac, renal or hepatic origin;
• •Presence of symptoms and/or trophic disorders of arterial, metabolic, neurological or orthopedic origin including traumas, arthritis, neuropathy;
• •One or more factors likely to affect venous symptoms such as recent childbirth, recent stripping, or deep or superficial venous thrombosis of the lower limbs during the previous 6 months;
• •Obese subjects (BMI \> 30);
• •Hypersensitivity to active principles contained in the tested food supplement (diosmin);
• •Patients considered smokers (≥10 cigarettes/day);
• •Patients with concomitant or history of addiction to alcohol, spices or drug abuse;
• •Pregnant women, nursing mothers, or women (only if childbearing potential) not using adequate methods of contraception;
• •Participation in an interventional clinical study in the previous 30 days;
• •Presence of any clinically significant medical condition judged by the investigator to preclude the patient's inclusion in the study.