Finding studies
Finding studies
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Judith Kroep, MD, PhD
CONTACT
Els Verdegaal, PhD
CONTACT
Lead
Leiden University Medical Center
Study the feasibility and safety of TIL administration in the window of opportunity created by carboplatin-paclitaxel chemotherapy with or without interferon alpha (IFNα). Furthermore, exploratory studies will be performed to analyze and confirm the proposed underlying mechanisms. Intervention: Cohort 1 * Carboplatin-paclitaxel day1, q3 weeks, 6x, plus * TIL starting 14 days after the 2nd chemotherapy cycle, q3 weeks, 3x. Cohort 2 * Carboplatin-paclitaxel day1, q3 weeks, 6x, plus * TIL starting 14 days after the 2nd chemotherapy cycle, q3 weeks, 3x, plus * IFNα (3x10e6 U daily) starting one week before the first TIL infusion for 12 weeks in total.
Age
18–any
Sex
FEMALE
Healthy volunteers
Not accepted