The Multicenter Topic Trial

Exclusion Criteria

• •Current Diagnosis of Asthma
• •Known Diagnosis of Cystic Fibrosis
• •Use of Continuous Oxygen Therapy of greater than 2 liters per minute - patients on 2 liters of Oxygen or less will be excluded if they have been hospitalized for COPD in the prior year or had more than 2 exacerbations requiring steroids and/or antibiotics in the prior year.
• •Documented history of drug abuse within the last year
• •Subjects should not have a pulmonary exacerbation or changes in therapy for pulmonary disease within 28 days before receiving the first dose of study drug.
• •Cirrhosis or elevated liver transaminases \> 3X ULN
• •GFR \< 50 estimated by Cockroft-Gault
• •Any illness or abnormal lab finding that, in the opinion of the investigator might confound the results of the study or pose an additional risk in administering study drug to the subject.
• •Pregnant or Breastfeeding
• •Subjects taking moderate or strong inhibitors or inducers of CYP3A4, including certain herbal medications and grapefruit juice. (Excluded medications and foods including the drugs and foods listed in the IRB HSP application.)
• •Uncontrolled Diabetes
• •Recent (e.g 1year) arterial thrombotic events (peripheral arterial disease, thrombotic stroke)
• •Clinically significant arrhythmias requiring anti-arrhythmic agent(s) or conduction abnormalities that in the opinion of the investigator affect patient safety
• •A standard digital ECG demonstrating QTc \>450 msec for men and \> QTc 470 msec for women at screening. If QTc exceeds 450 msec for men and \> QTc 470 msec for women at the screening ECG, the ECG should be repeated 2 more times during the screening period, and the subject will be excluded if the average of the 3 QTc values is \>450 msec for men and \> QTc 470 msec for women.
• •Angina symptoms
• •History of MI or revascularization procedure within the last three years prior to screening
• •Clinically significant congestive heart failure (known LVEF \<= 45%, cor pulmonale, diastolic heart failure, etc)
• •Patients with stable coronary artery disease are eligible
• •History of stroke/CVA or non-skin cancer \<5 years prior