Feasibility and Safety of Hybrid Transvaginal Natural Orifice Transluminal Endoscopic Surgery for Colon Cancer

Inclusion Criteria

• •1. Female.
• •2. Age: over 18 and below 80 years old.
• •3. BMI \< 28 kg/m\^2.
• •4. American Society of Anesthesiologists score of class I to III.
• •5. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
• •6. Colonic adenocarcinoma by endoscopy with biopsy.
• •7. Tumor size ≤ 5 cm.
• •8. Involving a single colon segment:
• •1. Right colon from the ileocecal valve up to and including the hepatic flexure.
• •2. Left colon from the splenic flexure to the junction of the sigmoid and descending colon.
• •3. Sigmoid colon between the descending colon and the rectum (at least 15 cm from the dentate).
• •9. Clinical stage cT1, T2, or T3, cN0, N1, N2.
• •10. No advanced local disease that renders laparoscopic resection impossible.
• •11. No transverse colon cancer (between distal hepatic flexure and proximal splenic flexure).
• •12. No distant metastasis in preoperative studies.
• •13. Complete preoperative colonoscopy demonstrating no synchronous colon cancers.
• •14. Require one of the following elective operations that may be safely performed by current techniques:
• •1. Right hemicolectomy
• •2. Left hemicolectomy
• •3. Subtotal colectomy
• •4. Sigmoid colectomy
• •15. Patients who agree with participating in the clinical study with informed consents. And with willingness and ability to comply with the requirements of the study protocol including follow-up.