Hypofractionated Vs Conventional Fractionated Radiotherapy After Breast Conserving Surgery

Exclusion Criteria

• •T4 or M1 breast cancer
• •Supraclavicular or internal mammary nodes metastases
• •Pathologically confirmed DCIS only without an invasive component
• •Bilateral breast cancer or historically confirmed contralateral invasive breast cancer
• •Treated with neoadjuvant chemotherapy or neoadjuvant endocrine therapy
• •Multiple lesions can not be removed by single quadrantectomy
• •Suspicious unresected and microcalcification, densities, or palpable abnormalities (in the ipsilateral or contralateral breast)
• •KPS ≤ 70
• •Patients with severe non-malignant comorbidity in cardiovascular or respiration system
• •Concurrent or previous malignancy excluding basal or squamous cell carcinoma of the skin
• •Previous radiotherapy to the chest wall or regional lymph node areas
• •Patients with medical contraindication for radiotherapy: systemic lupus erythematosus, cirrhosis
• •Pregnant or lactating
• •Conditions indicating that the patient cannot go through the radiation therapy or follow up
• •Unable or unwilling to sign informed consent