Impact of Insomnia Treatment on Brain Responses During Resting-state and Cognitive Tasks

Exclusion Criteria

• •1. Older than 65 y.o. or younger than 25 y.o.
• •2. Contraindication to the MRI scanning
• •3. Current neurological disorder
• •4. Past history of brain lesion
• •5. Major surgery (i.e., requiring general anesthesia) in the past 3 months
• •6. Untreated thyroid disorder
• •7. Chronic pain syndrome self-reported as interfering with sleep
• •8. Recent and severe infection in the past 3 months
• •9. Active cancer, or remitted cancer with cancer treatment within the last 2 years
• •10. Stroke
• •11. Myocardial infarct
• •12. Arterial bypass or angioplasty
• •13. Pacemaker
• •14. Heart failure causing limitation of ordinary physical activity
• •15. Renal insufficiency
• •16. Sleep apnea with an apnea-hypopnea index \> 5/h
• •17. Restless legs syndrome with symptoms 3 days or more per week
• •18. Periodic limb movements during sleep with index \> 15/h
• •19. REM-sleep behavior disorder
• •20. Narcolepsy and other central disorders of hypersomnolence
• •21. Sleepwalking more than once/month
• •22. Having worked on night shifts or rotating shifts for more than 2 weeks in the last 3 months or expecting to do so during the study period
• •23. Severe mental disorders: bipolar disorder (Type I), schizophrenia, anxiety disorders, major depressive disorder, current substance use disorder, current post-traumatic stress disorder
• •24. Current suicidality
• •25. Frequent alcohol consumption (\>10 glasses/week) or use of cannabis (more than once a week) or illicit drugs (more than once a month)
• •26. Smoking cigarettes more than 10 cigarettes/day
• •27. Pregnant or breastfeeding women
• •28. Current psychotherapy or past cognitive-behavioural therapy for insomnia
• •29. Current use of medication for depression or anxiety
• •30. Unable to stop hypnosedative medications for at least 2 weeks prior to the first assessment
• •31. For good sleepers: insomnia symptoms more than 3 times/ week.