A Single Intraarticular Injection of Platelet-Rich Plasma on Pain and Physical Function in Patients With Ankle OA

Inclusion Criteria

• •Age of at least twenty years
• •Ankle pain lasted for at least 6 months, despite conservative treatment or inability to tolerate the side effects of medications
• •Ankle radiographs taken within 6 months (reviewed by the senior author) were equivalent to grade 1-4 osteoarthritis by the Kellgren Lawrence grading system
• •Average ankle pain of \> 3cm on a 10-cm visual analog scale (VAS)
• •Radiological evidence of bilateral ankle osteoarthritis was accepted if VAS pain in the contralateral ankle was \< 3 cm
• •Normal activity level, not bedridden or confined to a wheelchair, able to walk 30 meters without the aid of a walker, crutches or cane
• •No use of physical therapy or changes in shoes or orthotic devices during the study