Prehospital Kcentra for Hemorrhagic Shock

Exclusion Criteria

• •1. Age less than 18
• •2. Unknown time of injury
• •3. Out-of-hospital cardiopulmonary resuscitation
• •4. Known history of thromboembolic disorders or stroke or suspicion by EMS of a recent stroke
• •5. Known oral anti-coagulant use to include warfarin and novel anti-coagulants
• •6. Severe hypothermia (\<28°C)
• •7. Drowning or asphyxia due to hanging
• •8. Burns more than 20% total body surface area
• •9. Evidence of devastating blunt traumatic brain injury to include fixed and dilated pupils, asymmetric pupils and extrusion of brain matter
• •10. Isolated blunt or penetrating head injury
• •11. Isolated spinal cord injury
• •12. Ground level (same level) falls
• •13. Inability to obtain intravenous access
• •14. Inability to administer randomized therapy within 4 hours of ambulance notification
• •15. Known transfers and inter-facility transfers
• •16. Known Do Not Resuscitate (DNR) prior to randomization
• •17. Known or suspected pregnancy
• •18. Known prisoners
• •19. Patients who have activated the "opt-out" process