BR101801 in Adult Patients With Advanced Hematologic Malignancies(Phase I)

Exclusion Criteria

• •1. Presence of overt leptomeningeal or active CNS metastases, or CNS metastases that require local CNS-directed therapy or increasing doses of corticosteroids within the prior 2 weeks. Patients with treated brain metastases should be neurologically stable and off steroids for at least 2 weeks before administration of any study treatment.
• •2. Impaired cardiac function or clinically significant cardiac disease
• •3. Patients with interstitial pneumonia or history of drug-induced interstitial pneumonia/pneumonitis.
• •4. Human immunodeficiency virus (HIV) infection.
• •5. Patients who are positive for hepatitis B surface antigen (HBsAg), hepatitis B core antibody (HBcAb), or hepatitis C virus antibody (HCVAb).
• •6. Chronic liver disease or chronic hepatitis
• •7. Any gastrointestinal disorders interfering with study drug absorption or are unable to swallow tablets or capsules.
• •8. Malignant disease, other than that being treated in this study.
• •9. Prior PI3K inhibitor will be accepted in the dose escalation part of the study (Phase Ia) only.
• •10. For patients with lymphoma:
• •* Systemic antineoplastic therapy (including cytotoxic chemotherapy, alfa-interferon \[INF\], and toxin immunoconjugates) or any experimental therapy within 3 weeks or 5 half lives, whichever is shorter, before the first dose of study treatment.
• •* Therapy with tyrosine kinase inhibitor within 5 half-lives before the first dose of study treatment.
• •* Unconjugated monoclonal antibody therapies \< 6 weeks before the first dose of study treatment.
• •11. Patients receiving systemic chronic steroid therapy or any immunosuppressive therapy (≥ 10 mg/day prednisone or equivalent).
• •12. Use of any live vaccines against infectious diseases within 4 weeks of initiation of study treatment.
• •13. Use of hematopoietic colony-stimulating growth factors, thrombopoietin mimetics, or erythroid-stimulating agents ≤ 2 weeks prior to start of study drug.
• •14. Patients with a history of stroke or having active neurological symptoms, with the exception of chronic conditions which, in the opinion of the neurologist, Investigator, and the Sponsor, would not impact ongoing neurologic assessments while on study treatment.
• •15. Active infection requiring systemic or antiviral antibiotic therapy.
• •16. Subjects with active CMV infection.
• •17. Subjects receiving moderate or potent CYP3A4 inhibitors or inducers and are unable to withdraw until 2 weeks or 5 times longer than the half-life, whichever is shorter, before the first dose of study treatment.
• •18. Major surgery within 2 weeks of the first dose of study treatment (mediastinoscopy, insertion of a central venous access device, and insertion of a feeding tube are not considered major surgery).
• •19. Radiotherapy within 2 weeks of the first dose of study treatment, except for palliative radiotherapy to a limited-field, such as for the treatment of bone pain or a focally painful tumor mass.
• •20. Presence of CTCAE ≥ Grade 2 toxicity (except alopecia, peripheral neuropathy, and ototoxicity, which are excluded if ≥ CTCAE Grade 3) due to prior cancer therapy.
• •21. Participation in an interventional, investigational study within 2 weeks or 5 half-lives, whichever is shorter, of the first dose of study treatment.
• •22. Any medical condition that would, in the Investigator's judgment, prevent the subject's participation in the clinical study due to safety concerns, compliance with clinical study procedures, or interpretation of study results.
• •23. Pregnant or lactating women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive human chorionic gonadotropin laboratory test.