A Therapy for Improving Symptoms in Patients With Acute Exacerbations of COPD by Hydrogen-Oxygen Generator With Neburlizer.

Exclusion Criteria

• •1. screening period of intravenous or oral administration of more than 80 mg / day of methylprednisolone or equivalent dose of other hormones or serious need for continuous non-invasive ventilation patients;
• •2. having a significant disease other than COPD, which, according to the researchers'judgement, would put the participants at risk for participating in the study or have an impact on the results of the study and the participants'ability to participate in the study;
• •3. other respiratory diseases: subjects with other active pulmonary diseases, such as active tuberculosis, lung cancer, bronchiectasis disease (CT showed repeated acute exacerbations of bronchiectasis disease) , sarcoidosis, idiopathic interstitial pulmonary fibrosis (IPF) , primary pulmonary hypertension, uncontrolled Sleep apnea (i.e. , according to the researchers, the severity of the disease would influence the study) ;
• •4. Lung Rehabilitation: Participants in the Lung Rehabilitation Program during the study period;
• •5. a history of severe heart disease such as acute myocardial infarction, congestive heart failure (NYHA Class III and above) , Severe Arrhythmia and other acute heart disease;
• •6. serious primary diseases of important organs and systems, such as acute stroke, hypertension above moderate after treatment, active gastric ulcer, diabetes Mellitus (serious complication) , malignant tumor, etc.
• •7. confirmed and suspected cases of lung cancer;
• •8. a history of one or more lobectomies;
• •9. limited understanding and poor compliance;
• •10. lack of or restricted legal capacity;
• •11. those who have participated in clinical trials of other drugs or medical devices within 30 days prior to screening but have not reached the end point of the trial;
• •12. pregnant, lactating women and women of childbearing age who do not agree to effective contraceptive measures during the study period;
• •13. Persons with mental or physical disabilities;
• •14. a suspected or confirmed history of alcohol or Drug Abuse;
• •15. those who are known to be intolerant to inhalation therapy;
• •16. AST, ALT were 3 times higher than the normal upper limit, creatinine ≥176.8 MMOL / l;
• •17. shock or other Hemodynamics instability;
• •18. people with active Hepatitis A, hepatitis B, HIV, tuberculosis, and Infectious Disease Connective Tissue Disease;
• •19. intravenous hormone therapy for more than 5 days after an acute episode;
• •20. non expectorant antioxidants, including high doses of vitamin C and Vitamin E;
• •21. the researcher did not consider it appropriate to participate in this study.