PRIMARY OBJECTIVES:
I. To assess whether perfusion changes to the liver following portal vein embolization (PVE) correlate with hypertrophy of the future liver remnant (FLR).
SECONDARY OBJECTIVES:
I. To assess perfusion changes to liver tumors following PVE. II. To assess whether PVE may affect tumor growth.
OUTLINE:
Prior to PVE, patients undergo CT perfusion scan of the liver and liver biopsy over 15 minutes. Patients undergo a second CT perfusion scan immediately after PVE and a third CT perfusion scan 3-6 weeks post PVE.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Patients planned to undergo major liver resection for cancer who need PVE to increase the size of the FLR prior to surgery.
Patients who are able to understand and give consent to participate in the study.
You may not be if
Pregnant or nursing.
Allergy to iodinated contrast which cannot be safely pre-medicated.
History of severe renal dysfunction (glomerular filtration rate \[GFR\] \< 30 mL/min/1.73 square meters). Patients with a GFR between 30-50 mL/min/1.73 square meters will receive the standard contrast-induced nephropathy prophylaxis at our institution (i.e. N-acetylcysteine and sodium bicarbonate \[150 mEq/L\] in D5W intravenous).
Clareo Health | CT Perfusion Scans in Detecting Changes in Blood Flow to the Liver After Portal Vein Embolization
