Clinical Application of ctDNA in Early Screening of Breast Cancer

Inclusion Criteria

• •Written informed consent must be obtained and documented according to the local regulatory requirements prior to beginning specific protocol procedures.
• •Age of at least 18 and at most 70 years.
• •Normal people who works as the volunteers.
• •Benign breast disease patients should be diagnosed with confirmed pathology after surgery.
• •Breast cancer patients should be diagnosed with confirmed pathology after surgery, and with no clinical evidence of local recurrence or distant metastases. Complete staging work-up within 3 months prior to registration, which should be earlier than TNM IIA stage.
• •Adequate organ function including normal red and white blood count, platelets, serum creatinine, bilirubin, and transaminases within normal range of the institution.