Rehabilitation for Patients With Pulmonary Hypertension

Exclusion Criteria

• •PH of any cause other than permitted in the entry criteria, e.g. concomitantly to portal hypertension, complex congenital heart disease, reversed shunt, HIV infection, suspected pulmonary veno-occlusive disease based on pulmonary edema during a previous vasoreactivity test or on abnormal findings compatible with this diagnosis (septal lines or pulmonary edema at high resolution computer tomography), congenital or acquired valvular defects with clinically relevant myocardial function disorders not related to pulmonary hypertension or unclear diagnosis
• •Patients with signs of right heart decompensation
• •Walking disability
• •Acute infection, pyrexia
• •Any change in disease-targeted therapy within the last 2 months
• •Any subject who is scheduled to receive an investigational drug during the course of this study
• •Severe lung disease: FEV1/FVC \<0.5 and total lung capacity \<70% of the normal value
• •Active myocarditis, instable angina pectoris, exercise induced ventricular arrhythmias, decompensated heart failure, active liver disease, porphyria or elevations of serum transaminases \>3 x ULN (upper limit of normal) or bilirubin \>1.5 x ULN
• •Hemoglobin concentration of less than 75% of the lower limit of normal
• •Systolic blood pressure \<85 mmHg
• •History or suspicion of inability to cooperate adequately