Lead Sponsor

Institut Claudius Regaud

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•1. Age ≥ 18 years old
•2. Patient with histologically proven locally advanced head and neck cancer (Oropharynx, hypopharynx, larynx, nasopharynx, oral cavity, sinuses, nasal cavities, ethmoid sinus, cavum, salivary glands)
•3. Cancer with nodal involvement (at least T3 or involved node \>2 cm)
•4. Eastern Cooperative Oncology Group performance status 0 or 1
•5. No previous curative treatment for head and neck cancer (surgery and/or radiotherapy and/or chemotherapy)
•6. Indication of exclusive radiotherapy (+/- chemotherapy) validated in multidisciplinary meeting
•7. Patient affiliated to the french social security system.
•8. Patient must provide written informed consent prior to inclusion in the study and any study-specific procedure.

•1. Patient with metastatic cancer
•2. Eastern Cooperative Oncology Group performance status ≥ 2 (due to comorbidities)
•3. Patient with recurrent disease
•4. Patient who required urgent surgical treatment
•5. Contraindications to radiotherapy
•6. History of cancer within 5 years
•7. Patient already included in another therapeutic trial
•8. Pregnant or breastfeeding women
•9. Any psychological, familial, geographical or sociological condition potentially preventing the medical follow-up and/or study procedures
•10. Patient protected by law