Pharmacokinetics Centella Asiatica Product (CAP) in Mild Cognitive Impairment

Exclusion Criteria

• •1. Current smoking, alcohol or substance abuse according to DSM-V criteria
• •2. Women who are pregnant, planning to become pregnant or breastfeeding
• •3. Men who are actively trying to conceive a child or planning to within three months of study completion
• •4. Severe aversion to venipuncture
• •5. Abnormal laboratory evaluation indicating asymptomatic and untreated urinary tract infection
• •6. Cancer within the last five years, with the exception of localized prostate cancer (Gleason Grade \<3) and non-metastatic skin cancers
• •7. Comorbid conditions such as diabetes mellitus, kidney failure, liver failure, hepatitis, blood disorders, clinical symptomatic orthostatic hypotension, and unstable or significantly symptomatic cardiovascular disease
• •8. Significant disease of the central nervous system such as brain tumor, seizure disorder, subdural hematoma, cranial arteritis, or clinically significant stroke
• •9. Major depression, schizophrenia, or other major psychiatric disorder defined by DSM-V criteria
• •10. Medications: sedatives (except those used occasionally for sleep), central nervous system active medications that have not been stable for two months (including beta blockers, cimetidine, SSRIs, SNRIs), anticoagulants (i.e. Warfarin), investigational drugs used within five half-lives of baseline visit, systemic corticosteroids, neuroleptics, anti-Parkinsonian agents, narcotic analgesics, nicotine (tobacco, patches, gum, lozenges, etc.), Cannabis sativa (herb or edibles)
• •11. Non-Alzheimer dementia such as vascular dementia, normal pressure hydrocephalus or Parkinson's disease
• •12. Mini Mental State Examination (MMSE) score of \<20 or \>28 or CDR score \>1 or zero
• •13. Unwilling to maintain stable dosage of AD medications throughout study duration
• •14. Inability or unwillingness of individual or legal guardian/representative to give written informed consent.
• •15. Current drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements.