Lead Sponsor

Centre Hospitalier Universitaire de Besancon

Age

All ages

Sex

ALL

Healthy Volunteers

No

•Diagnosis of COPD using Gold 2017 criterion
•Optimal medical treatment of COPD, ie. inhaled steroids, long-acting β2-agonist, long-acting anticholinergic, according to GOLD 2017 guidelines.
•At least one acute exacerbation of COPD with hypercapnic respiratory failure
•Introduction of NIV distant to acute exacerbation of COPD with persisting hypercapnia (\> 7kPa) on arterial blood gas at rest.
•NIV equipment from the service provider "Don Du Souffle (DDS)".
•Patient able to give their consent

•Contraindication to NIV (consensus conference of SFAR-SPLF-SRLF)
•Obstructive sleep apnea with apnea/hypopnea index \> to 20/h
•BMI \> 35 kg/m2
•Low compliance with NIV treatment (\<3h per day)
•Acute exacerbation COPD during inclusion or pH \<7.30 in routine blood gas arterial
•Severe heart failure (New York Heart Association stage IV/IV)
•Unstable angina
•Severe arrhythmias
•Severe renal insufficiency stage \> 4
•Other conditions than COPD resulting in hypercapnia
•Pregnancy
•Patient without health insurance
•Patient excluded by another study