Efficacy of Zoledronic Acid + Colaren vs Zoledronic Acid + Conventional Treatment for Osteoporosis in HIV+ and HIV- Men

Inclusion Criteria

• •Adult males 18 to 65 years old.
• •HIV diagnosis (HIV positive group) or negative HIV serology (HIV negative group).
• •Patients receiving HAART and sustained virologic control for at least two years.
• •Patients meeting diagnostic criteria for osteoporosis.
• •Subjects willing to participate voluntarily in this study and give a written consent.
• •Estimated glomerular filtration rate \>60 mL/min (Using CKD-EPI formula).
• •Female patients.
• •Use of immunosuppressive o immunomodulatory treatment 90 days previous to selection.
• •Use of prohibited drugs for the study like: antiestrogens, corticosteroids (doses greater than 7.5mg of prednisone/day) 90 days previous to selection.
• •Use of hormone therapy.
• •Patients with history or actual use of chemotherapy.
• •Patients deprived of freedom or imprisoned patients with mental illnesses.
• •Participant is part of another clinical trial or nutritional program.
• •Hypogonadism diagnosis with not having received hormonal replacement previous to the study.
• •Primary osteoporosis diagnosis.