Active Surveillance in Early Lung Cancer

Inclusion Criteria

• •Patient at UVMCC.
• •Has pathologically proven recent diagnosis (≤180 days) of solitary or multifocal Stage T1a/b/c, N0, M0 \[AJCC Staging, 8th Ed.\] non-small cell lung cancer \[NSCLC\] or carcinoid tumors.
• •History \& physical ≤90 days prior to enrollment.
• •Tumors may have a solid component of any magnitude ≤3 cm.
• •Age ≥65 years old.
• •Charlson Comorbidity Index \[CCI\] ≥6 within 90 days prior to enrollment.
• •Zubrod performance status of 0-3 within 90 days prior to enrollment.
• •Deemed unresectable or "medically inoperable" due to medical co-morbidities. Otherwise operable patients who decline surgery are considered inoperable.
• •Eligible to receive treatment via SABR at the discretion of the treating oncologist.
• •CT scan of the chest (contrast preferred) ≤90 days of enrollment with slice thickness ≤3 mm.
• •Whole body PET scan ≤90 days prior to enrollment. \[Preferably before biopsy performed\]
• •Patient at UVMCC.
• •Patients who have been followed via active surveillance \> 180 days already may enroll in the correlative science only cohort for the purpose of blood draws only, regardless of reason active surveillance was chosen.
• •Pathologically proven diagnosis (\>180 days prior to enrollment) of solitary or multifocal Stage T1a/b/c, N0, M0 \[AJCC Staging, 8th Ed.\] non-small cell lung cancer \[NSCLC\] or carcinoid tumors.
• •History \& physical ≤90 days prior to enrollment.
• •Any age.
• •Any Charlson Comorbidity Index \[CCI\].
• •Zubrod performance status of 0-3 within 90 days prior to enrollment.
• •Can be medically operable or inoperable with any medical co-morbidities.
• •CT scan of the chest (contrast preferred) ≤90 days around (before or after) enrollment with slice thickness ≤3 mm. \[Frequency as deemed appropriate by managing oncologist\].
• •Whole body PET/CT scan \[Not required pre-enrollment, and frequency as deemed appropriate by managing oncologist\].