Study of microRNAs in a Decompensated Cirrhosis

Inclusion Criteria

• •Patients with cirrhosis (determined either by histopathology or by association of clinical signs of portal hypertension and hepatocellular insufficiency and radiological signs (dysmorphic liver, evidences of portal hypertension (collateral circulation, ascites)).
• •AND
• •Not refusing his / her participation in the study after information (or non-opposition of the person of confidence if the patient has a disorder of consciousness or impaired judgment (hepatic encephalopathy) at the time of inclusion) AND
• •Admitted within 48 hours for an episode of acute decompensation (acute decompensation group = AD group), which is defined by the sudden occurrence of one or more of the following clinical or biological symptoms:
• •* Jaundice
• •* Hepatic encephalopathy
• •* oedemato-ascitic decompensation
• •* Gastro-intestinal bleeding
• •* Acute renal failure (according to AKIN criteria (22)) and / or hyponatremia
• •* Degradation of hepatocellular functions (decrease of prothrombin time and factor V measured in blood, increase of bilirubinemia) OR
• •Outpatient follow-up for stable cirrhosis, not admitted in the last 6 months for an episode of acute cirrhosis decompensation (pathological control group)