Diagnosis of schizophrenia or other psychotic disorders, recent alcohol or substance use disorder, recent anorexia or bulimia nervosa

Previous failed trial of lurasidone, or had intolerable side effects of lurasidone

Significant active physical illness

Actively suicidal

ECT within the past 6 months

Recent pregnancy, abortion or miscarriage or plans to conceive during the study; currently lactating

Metal in the body that is not MRI compatible

Current, past or anticipated exposure to radiation

Currently taking an anticoagulant medication

18F-DOPA PET to Elucidate the Antidepressant Mechanism of Lurasidone in Bipolar Disorder