Oxytocin on Approach Bias and Craving

Exclusion Criteria

• •Positive urine drug screen (except marijuana).
• •Using cocaine, stimulants (other than nicotine and caffeine), amphetamines, hallucinogens, ecstasy, opiates, sedatives, pain pills, sleeping pills, or other psychoactive drugs within 2 weeks of the start of the study (except marijuana).
• •Marijuana use more than 3 times/week.
• •Current enrollment in an alcohol, or other drug treatment program or current legal problems relating to alcohol, or other drug use.
• •Currently trying to quit alcohol use.
• •History of major alcohol related complications within the preceding 2 years (liver failure/cirrhosis, pancreatitis, esophageal varices, etc.).
• •Has a history of atrophic rhinitis, recurrent nose bleeds, cranial surgical procedures, hypophysectomy, chronic congestion, or sinus problems.
• •Has a history of cardiac arrhythmia.
• •Clinically significant medical or psychiatric illness requiring treatment as determined by screening blood tests, medical history, and/or physical exam performed or reviewed by the study physician.
• •Severely low blood (\< 90/50) pressure or uncontrolled high blood pressure (\>160/100).
• •SGPT/ALT or SGOT/AST values greater than 2x upper limit of normal.
• •BAC level \> 0.00% at the beginning of screening visit (within margin of error of detection).
• •Has a neurological dysfunction or psychiatric disorder (confirm with study physician).
• •Has a history of brain trauma (confirm with study physician).
• •Has an allergy or intolerance to oxytocin.
• •Has received an investigational drug within 30 days of Screening Visit.
• •Has any MRI scanning contraindications.
• •Has a history of claustrophobia.