Prevention of Hypertensive Injury to the Brain by Intensive Treatment of Blood Pressure After Intracerebral Haemorrhage (PROHIBIT-ICH)

Eligible participants will be identified from acute stroke or high dependency units or outpatient clinics (neurology, geriatric, and neurosurgery) by a member of the research practitioner or member of research/clinical teams. Patients may be under the care of stroke physicians, geriatricians, neurologists, or neurosurgeons. Baseline: At baseline, the following trial specific procedures will be carried out after consent as a requirement for the study to commence: * Medical history and demographic data recorded * Blood pressure medication and dose recorded * Blood pressure (BP), three seated office measures * Blood test (venepuncture) * MRI brain * Cognitive assessment (Montreal Cognitive Assessment) * Completion of an EQ-5D questionnaire * 24-hour ABPM Randomisation will be done using a web-based system in a 1:1 group assignment ratio to intensive remote telemetric home BP monitoring (RT-HBPM)-guided BP lowering (intervention group) or local primary care alone (control group), with stratification by ICH location (lobar versus non-lobar). In the intervention group, BP medication will adjusted on the basis of daily review of BP measures by the study physician in the central BP-monitoring team to target during 1-3 months to target a daily mean HBPM BP \<120/80 mmHg. Intervention: The Telemetric Bluetooth home Blood Pressure-monitoring device will monitor participant's BP to keep the target of 120/80mm Hg, if this is not achievable then the BP medication will be adjusted accordingly in order to achieve a target of 120/80mm Hg at 3 months follow-up. BP readings (3 readings over 10-minutes in the seated position in the non dominant arm, unless hemiparesis) will be taken 3 times daily (early morning, early afternoon and evening). All BP data will be automatically transmitted centrally in real time to the device co-ordination site in Oxford. A dedicated research member will be responsible for checking all BP data daily on patients in the study, and will advise on adjusting medication according to a standard protocol based on the latest BHS guideline, to ensure that BP is lowered to the intervention arm target. The local study centre will send new prescriptions directly to patients (with communication simultaneously with the GP). For dose changes, advice will be given to participants by phone by the central study team. All medication changes will be notified to the local research team and GP; responsibility for BP treatment will be by the local PI. Follow up: 3 month follow-up : completion of 3 month clinical data, blood pressure recorded and completion of Modified Cognitive assessment, EQ-5D questionnaire and home blood pressure acceptability questionnaire. 24-hour ABPM to be performed at the time of the 3 month follow-up visit. 12 month follow-up (Final visit): completion of 12 month CRF, blood pressure recorded, and completion of cognitive assessment and EQ-5D questionnaire. 24-hour ABPM to be performed at the time of the 12 month follow-up visit. An MRI scan will be performed at baseline and the 12 month follow-up visit on all participants to identify markers of cerebral small vessel disease including: * change in white matter hyperintensity volume * change in white matter microstructure (DTI) * change in the number of CMBs * change in cerebral atrophy Primary outcomes: (a) BP study (i) Acceptability: (a) ≥50% of eligible participants who were approached to participate agreed to be recruited; (b) \<30% dropout from the intervention group (discontinuation of HBPM against the advice of the BP monitoring centre) prior to one month; (c) patient approval of the monitoring process in ≥70% of those who returned questionnaires. (ii) Safety: between-group difference in number of serious adverse events related to reducing BP. (iii) Efficacy: mean group difference in the change from baseline to 3-month follow-up assessment of systolic BP (mean of two sitting readings) in the intervention group versus the control group (b) Imaging study (i) Safety: evolution of new infarcts or ICH on 12-month follow-up MRI (i) Efficacy: the progression on MRI white matter hyperintensity (WMH) volume (T2-weighted fluid-attenuated inversion recovery (FLAIR), or T2-weighted images when FLAIR was unavailable) between baseline and 12-month follow-up. Secondary outcomes: 1. BP study: (i) between-group difference in mean daytime systolic BP change from baseline ABPM to 3-month ABPM; (ii) between-group differences at 3-month follow-up in assessment systolic BP and in mean daytime systolic BP on ABPM; (iii) between-group difference in number of BP-lowering drugs at follow-up; (iv) the maintenance of differences in BP after completion of centralised monitoring, assessed at 12-24-months follow-up. 2. Imaging study: neuroimaging outcomes including (but not limited to) the proportion of patients who develop new cerebral microbleeds (CMBs) over 1 year; number of new CMBs at 1 year; new infarcts or intracerebral haemorrhages at 1 year; change in mean diffusivity (MD), fractional anisotropy (FA) and other 3T DTI metrics; change in cerebral blood flow (CBF) on 3T PCASL; change in total brain volume, white matter volume and grey matter volume on 3T T1 volumetric images; composite neuroimaging measures (e.g summary SVD scores)