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Lead
Istanbul Saglik Bilimleri University
With
Namik Kemal University
Bosphorus University
The objective of this research protocol is to find audio-visual features which differentiates bipolar mani/ remission/ health/ simulation and predicts treatment response earlier and detect neurocognitive changes during mania/ remission and difference from the healthy control. During hospitalization in every follow up day (0th- 3rd- 7th- 14th- 28th day) and after discharge on the 3rd month, presence of depressive and manic features for patients was evaluated using Young Mania Rating Scale(YMRS) and Montgamery- Asberg Depresyon Scale (MADRS). Audiovisual recording is done by a video camera in every follow up day for patients and for healthy controls which includes also depression and mania simulation. Cambridge Neurophysiological Assessment Battery (CANTAB) were administered to both groups( for patients both in the manic phase and in the remission) to assess neurocognitive functions.
Age
18–65
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
diagnosis of BD type I, manic episode according to DSM-5 \[10\] given by the following doctor,
being informed of the purpose of the study and having given signed consent before enrollment.
You may not be if
being younger than 18 years or older than 60 years,
showing low mental capacity during the interview
expression of hallucinations and disruptive behaviors during the interview,
presence of severe organic disease,
presence of any organic disease that may affect cognition
having less than five years of public education
diagnosis of substance or alcohol abuse in the last three months (except nicotine and caffeine)
presence of cerebrovascular disorder, head trauma with longer duration of loss of consciousness, severe hemorrhage and dementia,
having electroconvulsive therapy in the last one year.
For the healthy control group, the following additional criteria were considered for exclusion
presence of family history of mood or psychotic disorder,
presence of psychiatric disorder during interview or in the past.
Clareo Health | Correlation of Audiovisual Features With Clinical Variables and Neurocognitive Functions in Bipolar Disorder, Mania
