Understanding the Roles of Hormones in Adipocyte Remodeling Following Menopause

Exclusion Criteria

• •Meet either of the following criteria:
• •Have all 3 of the major menopause-related symptoms \[hot flashes, mood swings, insomnia (trouble sleeping)\]
• •Have 2 of the major menopause-related symptom combinations \[hot flashes and mood swings, or hot flashes and insomnia (trouble sleeping)\]
• •Unstable weight in the last 3 months \[gain or loss \>7 lb (or 3.2 kg)\]
• •History of clinically diagnosed diabetes or a fasting blood glucose \>126 mg/dL
• •Chronic use of systemic glucocorticoids, antipsychotic/antidepressant medications, thiazolidinediones and other medications that cause clinically significant weight gain, weight loss or are known to make changes in fat cell number/size \*
• •Previous bariatric surgery (or other surgeries) for obesity or weight loss (\< 3 years ago)
• •Use of over the counter or prescription weight loss products
• •History of metabolic diseases (other than diabetes)
• •History of neurological disease
• •History of cardiovascular disease (or other chronic diseases)
• •Pregnant, planning to become pregnant, or breastfeeding
• •Use of hormone replacement therapy
• •Unwilling to discontinue any form or hormonal therapy (e.g., contraceptives including birth control pills, vaginal ring, injections, implant, or skin patch; hormonal supplements, etc.) upon enrollment (after the Screening Visit).
• •* Inconsistent use of medications listed above will be evaluated and left up to the discretion of the Medical Investigator to evaluate safety.