Association Between Coronary Flow Reserve and BH4 Levels in High CV Risk

Primary parameter : relationship between coronary flow reserve (CFR) and platelet/plasma BH2 and BH4 levels in patients with hypertension and concomitant cardiovascular risk factors. Secondary parameter: Levels of cGMP in platelets. 4\. Study design Three parallel groups of patients (n=15 per group): * Group 1 with normal coronary flow reserve (CFR ≥2.5) * Group 2 with reduced coronary flow reserve (CFR≤2.0) o Group 3 control subjects (without a high risk profile according to ESC score chart http://www.heartscore.org. ) matched for age (between 40 and 80 years of age) * and gender. 1/3 enrolled patients must be diabetic (Type2 diabetes)