Glucosamine and Chondroitin in Preventing Inflammation in Overweight Patients

Exclusion Criteria

• •Chronic medical illness, history of gastrointestinal, hepatic, or renal disorders, or inflammatory conditions (including autoimmune and inflammatory diseases)
• •Pregnancy or lactation
• •Currently on a weight-loss diet
• •BMI (body mass index) \< 25 or \> 32.5 kg/m\^2
• •Alcohol intake of greater than 2 drinks/day (2 drinks being equivalent to 720 ml beer, 240 ml wine or 90 ml spirits)
• •Current use of prescription or over-the-counter medications other than oral contraceptives and hormone secreting intrauterine device (IUD)s, multivitamin pills or infrequent use of aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs), or use of aspirin or NSAIDs more than 2 days per week
• •Abnormal renal, liver or metabolic test
• •Inability to swallow pills
• •Known allergy to shellfish
• •Not willing to take pills made from shellfish or animal sources
• •Intention to relocate out of study area within next 2 months
• •Any antibiotic use in the past 6 months