Effectiveness of an Online Intervention Targeting Cancer-related Fatigue

PRIMARY OBJECTIVES: I. To assess the effectiveness of an online multidisciplinary psychological training program delivered via a smartphone-based application (the Untire app) in reducing patient-reported fatigue in cancer patients and survivors. SECONDARY OBJECTIVES: I. To determine the dose-response association between use of the Untire app and reduction in patient-reported fatigue severity. II. To explore whether changes in positive and negative affect, depressive symptoms interact with the effects of the Untire app on fatigue severity. III. To explore the predictive value of genetic markers (single-nucleotide polymorphisms) and personality characteristics for effectiveness of the Untire app in reducing patient-reported fatigue. OUTLINE: Patients are randomized to 1 of 2 arms. ARM I: Patients use Untire application intervention after baseline up to 6 months. ARM II: Patients use Untire application intervention after 3 months up to 6 months.