Effects of Psilocybin in Concussion Headache

Exclusion Criteria

• •Axis I psychotic disorder (e.g. schizophrenia, bipolar I, depression with psychosis)
• •Axis I psychotic disorder in first degree relative
• •Unstable medical condition, severe renal, cardiac or hepatic disease, pacemaker, or serious central nervous system pathology
• •Pregnant, breastfeeding, lack of adequate birth control
• •History of intolerance to psilocybin, LSD, or related compounds
• •Drug or alcohol abuse within the past 3 months (excluding tobacco)
• •Urine toxicology positive to drugs of abuse
• •Use of vasoconstrictive medications (i.e. sumatriptan, pseudoephedrine, midodrine) within 5 half-lives of test days
• •Use of serotonergic antiemetics (i.e. ondansetron) in the past 2 weeks
• •Use of antidepressant medication (i.e. TCA, MAOI, SSRI) in the past 6 weeks
• •Use of steroids or certain other immunomodulatory agents (i.e. azathioprine) in the past 2 weeks