The TESLA Trial: Thrombectomy for Emergent Salvage of Large Anterior Circulation Ischemic Stroke

Exclusion Criteria

• •1. Females who are pregnant, or those of child-bearing potential with positive urine or serum beta Human Chorionic Gonadotropin (HCG) test
• •2. Known severe allergy (more than a rash) to contrast media uncontrolled by medications
• •3. Refractory hypertension (defined as persistent systolic blood pressure \>185 mmHg or diastolic blood pressure \>110 mmHg)
• •4. CT evidence of the following conditions:
• •* Midline shift or herniation
• •* Evidence of intracranial hemorrhage
• •* Mass effect with effacement of the ventricles
• •5. Computed Tomography Angiography (CTA) evidence suggestive of difficult endovascular access per the treating interventionalist
• •6. Presence of cervical ICA occlusion (e.g., related to atherosclerotic disease or dissection)
• •7. Rapidly improving neurological status prior to randomization to NIHSS \<6
• •8. Bilateral strokes or multiple intracranial occlusions
• •9. Intracranial tumors
• •10. Known hemorrhagic diathesis, coagulation factor deficiency, or on anticoagulant therapy with an International Normalized Ratio (INR) of \>3.0 or Partial Thromboplastin Time (PTT) \>3 times of normal
• •11. Baseline platelet count \<30,000 per microliter (µl)
• •12. Life expectancy less than 90 days prior to stroke onset
• •13. Participation in another randomized clinical trial that could confound the evaluation of the study
• •14. Any other condition (in the opinion of the site investigator) that precludes an endovascular procedure or poses a significant hazard to the patient if an endovascular procedure was performed