Efficacy of Pioglitazone Hydrochloride and Metformin Hydrochloride Tablets on the Patients With Newly Diagnosed Type 2 Diabetes Mellitus Combined With Non-alcoholic Fatty Liver Disease

Exclusion Criteria

• •1. type 1 diabetes or secondary diabetes;
• •2. suffering from other liver diseases, such as hepatitis, self - free liver, etc.
• •3. abnormal thyroid function (in the active period), or the need for long-term oral and intravenous glucocorticoids to treat patients;
• •4. patients with severe renal dysfunction or renal disease (eGFR\<60);
• •5. in those with abnormal liver function, Alanine transaminase(ALT) or Aspartate transaminase(AST) was more than 3 times the normal upper limit.
• •6. people with serious gastrointestinal diseases such as peptic ulcers and chronic diarrhea;
• •7. patients with severe cardiopulmonary disease, cerebrovascular disease or stents;
• •8. hemopoietic system diseases such as serious primary diseases, hemoglobin \< 100g/L or need regular transfusion treatment;
• •9. pregnant, breast-feeding, women of childbearing age who are unwilling to contraception during the study period;
• •10. chronic cardiac insufficiency, the classification of heart function III level and above;
• •11. uncontrolled malignant tumor, and the history of bladder cancer.
• •12. acute complications of diabetes;
• •13. the use of other drugs for diabetes and liver disease;
• •14. patients who had participated in other clinical studies within three months;
• •15. people who have known allergies to this kind of drugs are known.
• •16. it is impossible to guarantee the effect or the safety judgment of the drug or the person who is unable to cooperate with the mental illness.