Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Ataturk University
Age
15–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
1. Chronic migraine diagnosis according to International Classification of Headache-2 Disorders (ICHD)
2. w/o pregnancy or breastfeeding.
3. w/o acute or chronic psychiatric disorders.
4. w/o nephrolithiasis.
5. w/o medication of anticoagulant and antiaggregant.
6. w/o allergy to topiramate or bupivacaine.
7. w/o prophylaxis within the last three months with any of; propranolol, nebivolol, topiramate, valproate, venlafaxine, duloxetine, amitriptyline, flunarizine.
8. w/o previous history of peripheral nerve block, botulinum toxin or acupuncture.
9. w/o history of multiple sclerosis, movement disorders, epilepsy, stroke, and tumor.
J-w/o chronic systemic diseases including hypertension, cardiac insufficiency, diabetes, pulmonary disease, kidney disease, liver disease, and peripheral arterial disease.
You may not be if
1. Lost to follow up within the pretreatment period during the detoxification therapy after the detoxification therapy
2. could not tolerate the peripheral nerve block or topiramate
