Placement of Antibiotic Powder in Wounds During the Emergency Room

Exclusion Criteria

• •Time from injury \> 24 hours.
• •Subjects who have received acute operative care (e.g., washout in the operating room or fixation) of the open fracture at an outside facility.
• •Subject or LAR speaks neither English nor Spanish. Note that subjects that are unable to participate in the consent process (e.g. intoxication, poly-trauma, will be enrolled into the observational arm where passive data collection will occur).
• •High-potency antibiotic powder or solution applied to the wound prior to enrollment. Simple ointment (i.e., bacitracin ointment) or antibiotic-impregnated dressings will be permitted.
• •Documented allergies or serious reactions to vancomycin. History of uncomplicated "red man syndrome" will not be considered a reason for exclusion.
• •Pregnant subjects. If the subject is a female of childbearing potential, and she states that she is likely to be pregnant, a pregnancy test will be performed; if negative, the subject will be eligible for enrollment.
• •Prisoners.
• •Participation in other clinical research involving investigational antimicrobial products within 30 days of randomization.