Air Pollution: Strategies for Personalized Intervention to Reduce Exposure

Exclusion Criteria

• •1. Inability for mental or physical reasons to understand and comply with the informed consent process and/or the study protocol procedures including wearing face mask (i.e: advanced COPD/lung disease requiring use of frequent inhalational or nebulizer treatments) per investigator discretion.
• •2. Obesity with arm circumference \>18 inches preventing accurate BP determination during ABPM monitoring
• •3. Significant hemodynamically unstable CV disorder including uncompensated heart failure, refractory angina, uncontrolled arrhythmias, critical valvular heart disease and severe hypertension. (as further described in Appendix B) at screening
• •4. ESRD on dialysis or patients that have received dialysis within 14 days prior to screening
• •5. Subject has a history of infection with human immunodeficiency virus
• •6. Subject has a history of alcohol or substance abuse within the 6 months prior to the screening
• •7. Advanced COPD on home oxygen
• •8. Past diagnosis of sleep apnea either untreated or treated with CPAP
• •9. History of malignancy including leukemia and lymphoma (but not basal cell skin cancer, cured squamous cell cancer and localized Prostate cancer) AND/OR any severe, life-threatening disease AND/OR history of drug abuse within the last 2 years
• •10. Regular use of any over-the-counter drug, recreational medication including stimulants (amphetamines) and/or complimentary or herbal therapy that might impact study outcomes including BP and insulin sensitivity per investigator discretion.
• •11. In women of childbearing age: pregnancy, non-use of approved method of birth control, intent to get pregnant during the study period
• •12. Patients with passive home cigarette smoking
• •13. Other medical or psychosocial conditions or life circumstances that may put the subject at increased risk of participation or jeopardizes the scientific integrity of the study, as determined by the investigators
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