Xanthohumol Metabolism and Signature

Exclusion Criteria

• •History of any chronic disease including, but not limited to: diabetes (type 1 or 2); uncontrolled hypertension; coronary artery disease resulting in angina; cardiovascular disease requiring percutaneous coronary intervention (PCI), bypass, or past myocardial infarction or stroke; blood disease including current anemia; cancer (except non-melanoma skin cancer) within the last year or still requiring chemotherapy or hormonal therapy; chronic kidney disease; liver disease including viral hepatitis, non-alcoholic fatty liver disease, or alcoholic hepatitis/cirrhosis; any immunocompromising condition including human immunodeficiency virus/acquired immunodeficiency syndrome or organ transplant requiring anti-rejection medications; chronic osteoarthritis requiring joint replacement or daily use of NSAIDs; chronic endocrine condition including but not limited to: Cushing's, Addison's, Hashimoto's thyroiditis, Grave's disease, etc.
• •Body Mass Index (BMI) less than 20 (underweight) or greater than 30 (obese)
• •Consumption of more than 1 microbrew beer per day
• •Use of NSAIDs more than once per week for headaches, routine aches/pains, etc.
• •Use of any prescription drugs, including oral contraceptives (due to potential interference with mechanisms under investigation)
• •Use of prescription opioids for any reason within the past 3 months
• •Use of prescription corticosteroids for any reason within the past 3 months
• •Free of acute viral or bacterial infection, or recent infection within the last 14 days or still requiring prescription medication for treatment
• •Free of recent acute trauma occurring within the last 14 days
• •Currently or recently (within last 14 days) taking any dietary supplements containing xanthohumol flavonoids, or other known herbal "anti-inflammatories" including: curcumin, turmeric, fenugreek, hops, rosemary, ginger, white willow, Devil's claw, fish oil (doses\>1 g/day), or quercetin. Candidates will be given the option to "wash out" for 14 days and re-contact the study team.
• •Currently receiving intravenous nutrition support therapy (or within the last 30 days)
• •Currently taking anti-coagulant or anti-platelet prescription medications (or they were taken within the last 30 days)
• •Currently taking antibiotic, antiparasitic, or antifungal medications orally or intravenously (or they were taken within the last 30 days)
• •Initiation of or changes to supplements or medications within 30 days prior to screening
• •Initiation of or changes to an exercise regimen within 30 days prior to screening
• •Initiation of or changes to a food plan within 30 days prior to screening
• •Current involvement or within 30 days prior to screening of a significant diet or weight loss program, such as NutriSystem, Jenny Craig, Atkin's or other low-carb diet programs, or very low-calorie liquid diet programs (such as optifast, medifast, and/or HMR)
• •Hospitalization (for any reason other than an elective medical procedure) within 3 months prior to screening
• •Gastrointestinal surgery within 3 months prior to screening
• •Undergoing UV therapy (e.g. treatment for skin conditions such as psoriasis).
• •Engaging in vigorous exercise more than 6 hours per week.
• •Women who are lactating, pregnant or planning pregnancy within the next four months
• •Typical intake of more than 2 alcohol-containing beverages per day, more than 14 per week, or more than 4 in any single day within the past 28 days
• •Use of recreational drugs/substances (such as but not limited to cocaine, phencyclidine (PCP), and methamphetamine) within 30 days of screening
• •Currently participating in another interventional research study or participated in another interventional study within 30 days of screening