Daily vs. Every Other Day Oral Iron Supplementation in Patients With Absolute Iron Deficiency Anemia

Exclusion Criteria

• •• Pregnancy
• •* Currently breastfeeding
• •* Known history of inflammatory bowel disease
• •* Known history of celiac disease
• •* Known history of thalassemia or thalassemia trait
• •* Known inherited bleeding disorder
• •* Known intolerance or lack of response to oral ferrous gluconate, sulfate or fumarate in the last 12 weeks
• •* Multivitamin and mineral supplements (35 mg or more of elemental iron per day) in the 2 weeks prior to randomization
• •* Allergy to oral iron
• •* Allergy to any of the following medicinal and non-medicinal ingredients in ferrous sulfate: ferrous sulphate, calcium citrate, crospovidone, FD\&C Red #40-Aluminum lake, FD\&C Yellow #6-Aluminum Lake, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, purified water, talc titanium dioxide
• •* Allergy to any of the following medicinal and non-medicinal ingredients in vitamin C: Ascorbic acid, Colloidal silicon dioxide, croscarmellose sodium, magnesium stearate, microcrystalline cellulose and stearic acid
• •* Intravenous iron therapy in the past 12 weeks
• •* On anticoagulant therapy (e.g. warfarin, apixaban, dabigatran, edoxaban, rivaroxaban) initiated in the past 6 months
• •* Surgery planned in upcoming 12 weeks
• •* Chemotherapy planned in upcoming 12 weeks
• •* Blood donation planned in upcoming 12 weeks
• •* Previously enrolled in the study
• •* Creatinine clearance less than 30 mL/min
• •* Hemoglobin less than 80 g/L with active bleeding (defined as WHO grade 2 bleeding or higher in the past week)