Pathological or clinical diagnosis of retroperitoneal/para-vascular lymph node metastases, and located below the level of renal veins.
The treatment target is no evidence of disease (NED), including 3 cohorts:
A. Initial treatment (primary lesion + retroperitoneal LN oligometastasis); B. Postoperative retroperitoneal/paravascular LN oligometastase; C. Postoperative retroperitoneal/paravascular LN metastasis with other organ metastases (up to NED)
ECOG PS 0-2
Ability to follow the program during the study period
Signing written informed consent
You may not be if
Retroperitoneal LN metastasis is above the level of the renal vein.
Unable to reach NED.
Previous pelvic radiotherapy, the field of irradiation overlaps with this time.
Pregnancy or breastfeeding women.
Those with other history of malignant disease in the last 5 years, except for cured skin cancer and cervical carcinoma in situ.
If there is an uncontrolled history of epilepsy, central nervous system disease or mental disorder, the investigator may determine that the clinical severity may hinder the signing of informed consent or affect the patient's oral medication compliance.
Clinically severe (ie, active) heart disease, such as symptomatic coronary heart disease, New York Heart Association (NYHA) class II or more severe congestive heart failure or severe arrhythmia requiring medication intervention, Or a history of myocardial infarction in the last 12 months
Organ transplantation requires immunosuppressive therapy
Severe uncontrolled recurrent infections, or other serious uncontrolled concomitant diseases
Subjects Blood routine and biochemical indicators do not meet the following criteria: hemoglobin ≥ 90g / L; absolute neutrophil count (ANC) ≥ 1.5 × 109 / L; platelets ≥ 100 × 109 / L; ALT, AST≤2.5 times normal upper limit; ALP≤2.5 times normal upper limit; serum total bilirubin \<1.5 times normal upper limit; serum creatinine \<1 times normal upper limit; serum albumin ≥30g/L
Clareo Health | CRT Versus Surgery for Retroperitoneal or Paraaortic Lymph Node Recurrence of CRC
