A Drug-Drug Interaction Study in Healthy Volunteers of the Effects of Tucatinib

Exclusion Criteria

• •Any condition affecting drug absorption (including stomach or intestinal surgery)
• •Significant history of metabolic, allergic, dermatological, hepatic, renal, hematological, pulmonary, cardiovascular, gastrointestinal, neurological, respiratory, endocrine, or psychiatric disorder
• •History of hypersensitivity, intolerance, or allergy to any drug compounds, food, or other substance (unless approved by Investigator)
• •Participation in a clinical study involving an investigational drug within the past 30 days
• •Use or intend to any prescription medications within 28 days prior to check in
• •Use of tobacco- or nicotine-containing products within 28 days prior to check in
• •History of hyperbilirubinemia
• •History of alcoholism or drug abuse within 2 years
• •History of regular alcohol consumption exceeding 7 drinks/week for female subjects or 14 drinks/week for male subjects
• •Positive hepatitis panel and/or positive human immunodeficiency virus (HIV) test