IvaBRAdine blocK of Funny Current for Heart Rate Control in permanEnt Atrial Fibrillation. (BRAKE-AF Study).

Exclusion Criteria

• •1. Previous treatment or patients with a known contraindication to Ivabradine or Digoxin or to any excipient of both drugs.
• •2. Paroxysmal or intermittent complete atrioventricular (AV) block in patients not carrying a pacemaker.
• •3. Decompensated heart failure requiring inotropic and I or intravenous diuretics in the week prior to randomization or in New York Heart Association (NYHA) functional class IV or on the cardiac transplant waiting list,
• •4. Acute pericarditis, acute myocarditis or constrictive pericarditis.
• •5. Obstructive hypertrophic cardiomyopathy.
• •6. Valvular disease requiring surgical or percutaneous correction.
• •7. Medical causes that justify poor control of heart rate: fever' anemia, hyperthyroidism, pheochromocytoma' etc.
• •8. Severe hypotension (blood pressure \<90/50 mmHg).
• •9. Concomitant treatment with potent cytochrome P450 3A4 inhibitors such as azole antifungals (ketoconazole, itraconazole), macrolide antibiotics (clarithromycin, oral erythromycin, josamycin, telithromycin) HIV protease inhibitors (nelfinavir, ritonavir) and nefazodone.
• •10. Severe renal insufficiency (CrCl \<30 ml/Kg/min) or in a hemodialysis program.
• •11. Severe hepatic insufficiency.
• •12. Major surgery (including cardiac surgery) in the month prior to randomization.
• •13. Severe concomitant illness that supposes a llfe expectancy of less than one year.
• •14. Impossibility of carrying out scheduled visits to the protocol.
• •15. Woman of childbearing age (under 50 years of age, except for those who present a gynecological report that proves the presence of menopause) and women who are breastfeeding.
• •16. Participation in a clinical trial in the previous 6 months.
• •17. Patients with acute myocardial infarction or unstable angina.
• •18. Patient with a recent stroke.
• •19. Patients with congenital long QT syndrome or treated with drugs that prolong this interval.