Weight Bearing Exercise in Preventing Frailty in Stage I-IIIA Breast Cancer Survivors

Inclusion Criteria

• •Post-menopausal (12 months without menstrual period: naturally, surgically, by hormone suppression).
• •History of early stage breast cancer (stage I, II, IIIa).
• •At least 6 months from chemotherapy.
• •May be receiving hormonal therapy during the study.
• •Currently disease-free, including a negative mammogram within 1 year.
• •Body mass index (BMI) between 25 and 40kg/m\^2.
• •In general good health with no acute or chronic disease that could worsen with weight bearing exercise.
• •Not currently on a prescribed diet nor reporting weight loss of \> 10 pounds (lbs) in previous 3 months.
• •Not currently participating in physical activity (PA) independently or a structured program (performing \< 120 min of low-intensity, low-impact exercise per week; and no weightlifting or similar physical activity).
• •Ability to participate in physical activity, not limited by severe disability (e.g., severe arthritic conditions); chronic back pain, or history or presence of diseases for which increased physical activity would not be advised.
• •No severe chronic disease, other than breast cancer (e.g., human immunodeficiency virus/acquired immunodeficiency syndrome \[HIV/AIDS\], kidney failure, liver failure, chronic obstructive pulmonary disease, congestive heart failure, Alzheimer?s, unstable angina, uncontrolled asthma, uncontrolled diabetes, uncontrolled hypertension).
• •No implanted cardiac pacemaker, cardiac defibrillator, or other implanted electronic medical equipment.
• •No history of drug or alcohol abuse.
• •Able to remain in a lying or sitting position for an extended period (\> 30 minutes).
• •No history or presence of a significant psychiatric disorder or any other condition that would interfere with participation in the trial.
• •Medical clearance by treating physician.
• •Willing to discontinue nonsteroidal antiinflammatory drug (NSAID) use, except Tylenol and baby aspirin (80mg), 1 week prior to blood draws.
• •Willing to maintain body weight during the study.
• •Can be reached by telephone.
• •Willing to complete consent process and sign informed consent form.