Identifying Novel Aging Targets for Treatment of Delirium

Exclusion Criteria

• •Diagnosis of dementia in electronic medical record at time of ICU admission
• •Blindness, deafness, or inability to understand English as this prevents ICU delirium assessment
• •Cognitive impairment prior to hospitalization (inability to follow instructions/comply with study/sign consent)
• •Score of \> 3.30 on Informant Questionnaire of Cognitive -Decline in the Elderly (IQCODE)\[34\]. Questionnaire will be given to family member or legally authorized representative.
• •Pregnancy/lactating/breastfeeding
• •Legally incapacitated: Prisoner/Ward of State
• •History of prior large vessel cerebrovascular accident (CVA)
• •History of neurologic disorder prior to ICU admission including multiple sclerosis, Parkinson disease, epilepsy, amyotrophic lateral sclerosis (ALS), Guillain-Barre Syndrome (GBS)
• •Psychiatric illness including schizophrenia, bipolar disorder, depression with psychotic features
• •Not expected to survive 24 hours
• •Judgment of investigator that subject participation could jeopardize subject health/safety or integrity of study
• •Active malignancy requiring treatment in the prior 6 months
• •Inability to return for study procedures
• •Inability to obtain consent